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Study: Hormone Cuts Pre-Term Births In High-Risk Women

RENEE MONTAGNE, host:

Now to medical care affecting the very beginning of life. In the U.S., about half a million babies are born prematurely each year. Premature birth is the leading cause of infant mortality, and for many, there has been little that can be done about it, until now. Reporter Gretchen Cuda-Kroen has the story of how a common hormone, progesterone, reduces the rate of premature delivery in high risk women.

GRETCHEN CUDA-KROEN: Kai Paul is the proud mother of a healthy one-year-old something that didnt always come easy. Early in her pregnancy Paul learned that she had a condition known as a short cervix. It affects anywhere from two to six percent of pregnant women, and it increased her chances of delivering a premature baby by 50 percent, or more.

Ms. KAI PAUL: It was very, very, traumatic. Once they actually were telling me all the things that could possibly happen to the baby. nd the, like, long term problems that he could possibly have, it was something that, you know, it just haunted me every day until he was born.

CUDA-KROEN: Pauls doctors put her on strict bed rest but other than that, she says she was told there was nothing else they could do.

Ms. PAUL: Im faced with the tragic news that I could possibly lose my baby, you know, before he even had a chance and there was no solution to it but bed rest?

CUDA-KROEN: But Paul was fortunate. She was enrolled in a study by the National Institutes of Health that was testing the effectiveness of a vaginal gel containing the hormone progesterone, in extending her pregnancy to term. Roberto Romero, one of the studys authors explains progesterone keeps a womans cervix long and closed, and her uterine muscles quiet. Before delivery, the cervix shortens and opens. But some women have a progesterone deficiency that causes that to happen too soon.

Dr. ROBERTO ROMERO (Study Author): A short cervix is the most powerful predictor of preterm delivery that we currently have in medicine, and in general the shorter the cervix the higher the risk for preterm delivery.

CUDA-KROEN: For Paul, this gave her and her son a chance. She says she applied the gel every night herself with a tampon-like applicator throughout her pregnancy, and it worked. In fact, the study showed that progesterone reduced the rate of preterm deliveries before 33 weeks by 45 percent. Romero says this is a huge leap forward that will change the practice of medicine.

Dr. ROMERO: I believe that this is a game changer. One, we have a way to screen, and second we have a way to intervene before the patient develops premature labor.

CUDA-KROEN: Obstetrician Jay Iams of Ohio State agrees. He says not only is the screening and treatment simple, inexpensive, and virtually without risk, this is the second study to indicate that progesterone can be of benefit to women diagnosed with a short cervix something that makes this study particularly powerful.

Dr. JAY IAMS (Obstetrician): And thats what this study does. It is the one that will close the deal so to speak, that this approach will help women with short cervix reduce their risk of premature birth.

CUDA-KROEN: Both doctors say that the results raise the question of whether all pregnant women should be screened for a short cervix, and whether the progesterone treatment can be useful in reducing the risks for women with a longer cervix as well.

For NPR News, Im Gretchen Cuda-Kroen in Cleveland.

(Soundbite of music)

MONTAGNE: This is NPR News. Transcript provided by NPR, Copyright NPR.

NPR transcripts are created on a rush deadline by an NPR contractor. This text may not be in its final form and may be updated or revised in the future. Accuracy and availability may vary. The authoritative record of NPR’s programming is the audio record.

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